Effect of moderate exercise on the fibrinolytic system in normal young men and women.

The value of drug treatment in angina pectoris can be accurately assessed by using reproducible treadmill exercise under controlled conditions. A "training" period to allow patients to become completely familiar with the test is of great importance, because during this period effort tolerance usually increases irrespective of drug therapy. The change in effort tolerance after pronethalol or propranolol, compared with placebo, was measured in 20 patients. A wide variation in response was obtained, but the mean improvement of 36% was highly significant (P<0.001).